Current Trends in Clinical & Medical Sciences in Iris Publishers

Turning Back the Clock: The Effect of the COVID-19 Response in Sub-Saharan Africa and Other Low- Income Countries Authored by Sanghvi Reema Introduction The COVID-19 pandemic has affected everyone across the world, either through the disease itself or with our response to the disease as healthcare professionals, for the better part of a year. In the matter of a few months, it managed to spread from its little corner of the world to a true pandemic. In response to this global pandemic many affluent nations have instituted lockdown procedures to protect their population, a practice that has been adopted by many low to low- middle income countries (LMICs) as well. Unfortunately, this pandemic does not take place in a vacuum, and individuals can have more than one condition with resultant needs outside their homes. This becomes readily apparent when considering someone receiving medical treatment for a disease such as HIV or TB, who may struggle keeping their treatment appointments. I

Active Filtering and Exchange of Indoor Air by Means of Mobile Air Conditioners to Avoid Infection by The SARS Cov-2 Virus Authored by Sebastian König Introduction In not actively ventilated rooms such as in schools, air exchange is insufficient, particularly during win- ter. Under the presence of COVID-19 or to reduce the CO2 concentration, the air must be filtered and refreshed as well as possible. A tracer clearance experiment using a mobile air conditioner e.g. from KRONE Kälte + Klima VertriebsmbH Germany is supposed to determine to what extent. In Szabadi [1]. the air exchange rate [n] = 1/h is introduced as a measure of air exchange. The exhaust volume flow [dV/dt] ⩒ = m3/h is related to room volume [V] = m3. The air exchange rate n is a multiple of the room volume. Reference values are n = 3/h <= n <= 6/h. The air conditioner in (Figure 1) comprises an air recirculation (5) and an active air exchange (6). The recirculation may also filter and cool the air. Here, the a

A Long Non-coding RNA and its Potential Role in Human Myeloid Leukemia Authored by David Reisman Introduction Over the past decade, long non-coding RNAs (lncRNAs) have been discovered to function as regulators of gene expression and numerous biological processes. They are transcribed from loci throughout the genomes of most eukaryotes [1-7]. and reports indicate that many lncRNAs are involved in the regulation of pluripotency and differentiation [8-14]. Although the mechanisms by which these lncRNAs function are still being explored, one model that has emerged states that nuclear lncRNAs modulate gene expression through interactions with histone modifying proteins and/or transcription factors [6-7, 12, 15-18]. Other lncRNAs function in the cytoplasm [19-21]. Lnc-MD1, for example, is a muscle-specific lncRNA that regulates muscle differentiation by binding to microRNAs (miRNA) and limiting their availability to regulate gene expression [9]. Another lncRNA, TINCR, is induced during

Plasma Biochemical Parameters of The Blood of Captive Adult Male and Female Black-Necked Pheasants (Phasianus colchicus), Gray Partridge (Perdix perdix) and Chukar Partridge (Alectoris chukar) in Bulgaria Authored by Slavko Naskov Nikolov Introduction The Black-necked pheasants or Southern Caucasus pheasants (Phasianus col. colchicus), Gray partridge (Perdix perdix) and Chukar partridge (Alectoris chukar) are birds from the order Galliformes, family Phasianidae and native to Europe and Asia. They have been widely introduced as game birds and are one of the world’s most hunted birds [1-2]. Over the last few years, industrial pheasant farms have been developed as a new agricultural activity for commercial production of meat in Europe, and the number of the pheasant population reared each year has increased exponentially [3-4]. Although it is well known that plasma biochemistry is important for medical diagnosis of disease in several bird species, limited information is available for phe

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Pharmacoeconomic Evaluation of Novel Oral Anticoagulants in Patients with Cardiovascular Diseases: A Systematic Review Authored by Ahmed Ibrahim Nouri Introduction For decades, the oral anticoagulant warfarin remained the gold standard of medical management for many cardiovascular diseases and main pharmacological agents for the prophylaxis of venous thromboembolism [1]. Among these cardiovascular patients, the vitamin K antagonists are especially beneficial to patients with venous thromboembolism and for the prevention of stroke. In terms of clinical consideration, warfarin displays several limitations and disadvantages. The narrow therapeutic window and vast drugdrug and drug-food interactions properties of warfarin render it clinically difficult to use [2]. Precise dose adjustment and frequent dose monitoring are of utmost importance because inappropriate dose can lead to many adverse clinical events. Warfarin over-dose will increase the risk of serious bleeding while under-dose