Iris Publishers - Current Trends in Clinical & Medical Sciences (CTCMS)

 Lymphadenectomy in the Treatment of Colon Cancer: A Survival Analysis

Authored by Irami Araújo Filho



Introduction

Colon cancer (CC) is one of the most prevalent neoplasms in the world. In Brazil, it is the fourth most common cancer. In 2018 the estimate of new cases was 36.360 (17.380 men/18.980women) [1]. Notwithstanding the high mortality, it is a curable disease when localized and restricted to the intestine [2]. The best therapeutic results are achieved through standard treatment, colectomy associated with lymphadenectomy (radical surgery). Cure occurs in up to 50% of patients when considering all stages of the disease. Nevertheless, relapse is still a major problem, contributing to the increase in deaths [3-5]. The prognosis and survival of each patient depend on correct staging, with TNM being the most used system. In this, the classification of “N” is given by the absolute number of metastatic lymph nodes (LN), where N1 will be considered from one to three lymph nodes and N2 above this value [6]. The presence of this lymph vascular invasion can distinguish stages II and III and alter the proposed treatment. According to current clinical evidence, adjuvant chemotherapy in the treatment of stage II-CC does not show an increase in survival, whereas, in stage III, its performance is indicated [4]. From this perspective, there would be impaired patient care if there were errors in lymph node count or histopathological positivity for malignancy [7].

Assessment of lymph node status is an alternative method, and one of the independent factors for the prognosis of WC. This is obtained by histopathological examination after radical surgery, in which reports express the number of resected lymph nodes (LNR) and the number of lymph nodes positive for tumor presence (LN+) [1,7-9]. Thus, in addition to lymphatic and vascular invasion, metastasis-free lymph nodes are considered a good prognostic factor. In addition to establishing proportionality, lymph node histological analysis provides additional information, such as the presence of extranidal extension (perinodal tumor cells), directly related to tumor aggressiveness [10].

The American Joint Committee on Cancer (AJCC) and the National Cancer Institute recommend that a minimum of 12 lymph nodes be examined in patients with CC to confirm the absence of lymph node involvement by the tumor [6]. This recommendation considers the number of LNs analyzed to be reflex of the radicality of lymph vascular mesenteric dissection in surgical resection and histopathological in the surgical specimen. In addition to being decisive for the elaboration of the therapeutic strategy of CC, the values of LNR and LN + are independent predictors that interfere with cancer outcomes. The overall survival and the likelihood of relapse, thus contributing to the definition of prognosis [11-13].

In this sense, it is essential to define the minimum number of LNs to be examined in a surgical specimen to determine the patient’s lymph node status as accurately as possible and to avoid sub staging, as the therapeutic approach is based on staging tumor completely. Based on the above, the present study evaluated the impact. It discussed the importance of quantifying the number of resected lymph nodes in the overall survival of patients diagnosed and treated for Colon Cancer in Natal, League of Cancer Hospital - State of Rio Grande do Norte. (RN) - Northeast Brazil.

Methods

A retrospective observational study of 80 patients was carried out at Dr. Luiz Antônio Hospital / League Against Cancer, a referral cancer hospital located in Natal - State of Rio Grande do Norte / Northeast Brazil, referring to the period between the years. From 2007-2014. The study was approved by the Research Ethics Committee of the League Against Cancer under protocol 044/044/2009, registered at Plataforma Brazil/National Commission of Research Ethics - CONEP/Ministry of Health. The study included all patients aged over 18 years with colon adenocarcinoma, confirmed by previous histopathological examination, who underwent radical surgery as a curative treatment, associated or not with radiotherapy and/or chemotherapy. Data were collected by reviewing medical records considering the following information: age, gender, origin, diagnosis, date of diagnosis (time of biopsy), TNM staging, type of surgical treatment, adjuvant treatment, disease recurrence, death´s age, and cause of death. All patients underwent surgical treatment alone or associated with chemotherapy and/or radiotherapy performed by members of the medical staff of Dr. Luiz Antônio Hospital. Cancer staging was performed following the TNM system, according to the American Joint Committee on Cancer. Overall survival was calculated considering the date of diagnosis. The non-parametric Kaplan-Meier and Wilcoxon methods were used to estimate and compare the overall survival rate using SPSS/IBM® version 25 statistical data analysis software. The results of the Wilcoxon test evidence were evaluated, considering the significance statistics level 5%.

Results

The sample of 80 patients was divided into three age groups: 15% aged <50 years, 47.5% aged 50-70 years, and 37.5% aged> 70 years. Regarding the epidemiological characteristics, the analysis of the sample group revealed that most of the patients were women from the interior of the state of NB. Regarding the clinical features, it was noticed that the incidence of CC was higher in the right colon. Regarding lymphadenectomy (radical colectomy), 70% of the patients had 12 or more LN analyzed in the histopathological examination of the surgical specimen, 15% <12 LNR, and in the remaining 15% there was no detection of LN by the pathologist (Table 1).

Discussion

The importance of the evaluation of resected lymph nodes in predicting the prognosis of patients with colorectal cancer is increasingly consolidated. The discussion about the objective of the study is how many lymph nodes would be necessary to dry during the surgery and to recover in the surgical specimen during the histopathological examination to obtain reliable results [14]. The main factors that may interfere in the evaluation of the number of NRLs are the surgical technique. methods applied in the pathology and characteristics of the patient (age; stage of the disease; among others) [15-17]. Regarding the surgical technique, the best results are attributed to complete mesocolic excision. The increased extension of the obtained surgical specimen promotes the resection of a more significant number of lymph nodes and provides sufficient material for one for adequate histological analysis. This fact does not increase perioperative morbidity and is associated with improved overall survival in stages I-III [18].

In the present study, all patients were operated by the same team of surgeons. who underwent standard surgical technique and opted for a broad and radical approach, reserving complete mesocolic excision in cases of rectal carcinoma. Histopathological analyses were similar in all cases, considering that the anatomical specimens were examined by the same group of pathologists who use standardized techniques and follow strict institutional protocols. Thus, possible biases that could exist in multicenter studies may be disregarded in the results presented [19]. Regarding the clinical characteristics of the patients, the distribution by age and sex is in agreement with the literature. as well as the survival rates. It is noteworthy that the present study considered the excision pattern of at least 12 lymph nodes for all age groups. as provided by the AJCC. However, some articles in the literature already consider age as an essential factor in determining the number of lymph nodes [20,21].

A Chinese study concluded that more than nine lymph nodes would be enough for patients over 80 years old, finding similar results concerning prognosis and survival [16]. The possible explanation would be the fact that the elderly have a modulated immune and inflammatory response concerning cancer and, thus, there is less involvement of regional lymph nodes by tumor cells. Moreover, in elderly patients, there is lymph node involution with aging [16].

On the other hand, a study involving 2360 patients younger than 40 years showed that resection of more than 22 lymph nodes was able to increase survival by 4% [17]. Although not the most prevalent age group for colorectal câncer, the diagnosis occurred at an advanced stage, with a higher number of affected lymph nodes, aggressive histological subtypes, which required more extensive intestinal resections and a more significant number of ganglia.

 

As for the stage of the disease, it is crucial to consider that the more advanced câncer, the more LN will be affected by the tumor, becoming larger and facilitating its resection. The explanation lies in the fact that the more massive disease, the deeper the intestinal wall penetration and mesenteric invasion, leading to a higher antigenic immune and inflammatory response in the regional lymph nodes. This promotes an increase in lymph node number and volume, but not necessarily metastatic positivity. Thus, carcinomas with T3 and T4 staging tend to have a higher number of resected lymph nodes [18].

A survey by Chandrasinghe et al. collected data from 131 patients with stage II and III CC who underwent curative resection surgery and whose surgical specimens had at least five lymph nodes evaluated in the histopathological examination. Prospectively analyzing the cancer outcomes, it was concluded that in patients whose surgical specimen had 14 or more NRLs, there was a better overall survival benefit (p = 0.005) compared to the other groups; rectal (n = 83/p = 0.03) and colorectal (n = 46/p = 0.08) cancer. Also, the number of LNs analyzed has been shown to affect postoperative survival in patients with or without LN +, concerning the more resected NLR, the better the long-term prognosis [20].

Downing et al. collected information from 128.071 patients diagnosed with colon adenocarcinoma from The Surveillance. Epidemiology. and End Results database from 1988-2005. The authors concluded that the optimal minimum number of resected NRLs for patients with and without LN +, a significant predictor of survival, is between 10-15 LN. It was also observed that the survival rate benefit in all analyzed subgroups continues to increase in proportion to the higher number of resected NRNs. indicating that patients continue to benefit at the rate that more NRs are examined. even after the optimal value established [21].

Rivadulla-Serrano et al. analyzing data from 148 patients diagnosed with CC / N0 and undergoing curative surgery between 1995-2001, concluded that dissection of a larger number of lymph nodes is related to improved survival rates in 05 years [11]. This conclusion was inferred since the rate in question was 63% in the group with <7 NLR. 80.6% in patients with 7-14 NLR and 91.8% in those> 14 NLR (p <0.01). Thus, the study recommended to obtain the largest amount of NLR possible and not to establish a minimum number of NL to be resected in operation and analyzed by histopathological examination [22].

Finally, Chen et al. concluded that the number of LN analyzed by histopathology during the examination of the surgical specimen correlates with clinical improvement and survival in patients with CC-N0 [23]. The study sample comprised data stored in the Surveillance, Epidemiology, and end Results of 82.896 patients who underwent CC curative surgery between the years 1988-2000. In this study, the sample was divided into four subgroups of patients based on the number of LN examined postoperatively: 0; 1-7; 8-15 and > 15 LNR. For all tumor stages, the increase in the number of lymph nodes evaluated in the histopathological examination increased the survival rate. Patients with less than 15 LN analyzed compared to the subgroup that had 1-7 LN resected experienced a 20.6% reduction in mortality regardless of other patient and tumor stage variables [21-23].

The results achieved by the studies described above validate the findings observed in the present research. Postoperative survival rates increased exponentially and proportionally to the increase in the number of LNR, confirming the fact that the LNR value is relevant for both correct CC staging and prognosis and survival prediction.

To read more about this article: https://irispublishers.com/ctcms/fulltext/lymphadenectomy-in-the-treatment-of-colon-cancer-a-survival-analysis.ID.000516.php

Indexing List of Iris Publishers: https://medium.com/@irispublishers/what-is-the-indexing-list-of-iris-publishers-4ace353e4eee

Iris publishers google scholar citations: https://scholar.google.co.in/scholar?hl=en&as_sdt=0%2C5&q=irispublishers&btnG=

Comments

Post a Comment

Popular posts from this blog

Iris Publishers - Current Trends in Clinical & Medical Sciences (CTCMS)

Image
A Long Non-coding RNA and its Potential Role in Human Myeloid Leukemia Authored by David Reisman Introduction Over the past decade, long non-coding RNAs (lncRNAs) have been discovered to function as regulators of gene expression and numerous biological processes. They are transcribed from loci throughout the genomes of most eukaryotes [1-7]. and reports indicate that many lncRNAs are involved in the regulation of pluripotency and differentiation [8-14]. Although the mechanisms by which these lncRNAs function are still being explored, one model that has emerged states that nuclear lncRNAs modulate gene expression through interactions with histone modifying proteins and/or transcription factors [6-7, 12, 15-18]. Other lncRNAs function in the cytoplasm [19-21]. Lnc-MD1, for example, is a muscle-specific lncRNA that regulates muscle differentiation by binding to microRNAs (miRNA) and limiting their availability to regulate gene expression [9]. Another lncRNA, TINCR, is induced during ...
Read more

Iris Publishers - Current Trends in Clinical & Medical Sciences (CTCMS)

Image
  External Cortical Femoral Implant in A THP A Long Term Follow Up of a Clinical Case Authored by Yves Cirotteau Everyone, in his practice, had patients with more or less severe brain dysfunction, one is hemiplegia [1]. What could happen for the patient from an orthopedic point of view, on the lower limb when such a disease happens? The reduced use of the limb reduces the pressure on the bearing bone and, from a physiological point of view, a reduction of the mineralization. The bone becomes osteoporotic [2]. The physical phenomenon is reversible when the pressure conditions are restored. Here are two examples. This patient had a right haemorrhagic stroke few years ago. He had a left hemiplegia and spent a long time in physiotherapy due to the difficulty to walk. Note the thin both femoral cortical due to the bad utilization of the left lower limb (Figure a). Few years later, he recovered a best walk. Note the very good thickening due to the best support of his body weight by the ...
Read more

Iris Publishers - Current Trends in Clinical & Medical Sciences (CTCMS)

Image
  The Psychology of Phenomenological Structuralism Authored by Paul Mocombe C Introduction This work highlights the psychology behind Paul C. Mocombe’s theory of phenomenological structuralism. The author posits a cognitive developmental psychology that is tied to the theory’s emergent logico-metaphysical materialist account regarding the formation, constitution, and perpetuation of the multiverse, consciousness, society, and the individual. Paul C. Mocombe’s structurationist theory of phenomenological structuralism, building on and synthesizing a form of M-theory with, mathematical elements of univon multiverse hypothesis, the quantum computation of ORCH-OR theory, Black Hole Big Bang Theory (BHBBT), structurationism, and the multiverse ideas of Haitian ontology/epistemology and quantum mechanics abductively posits that spacetime is fundamental; and consciousness is an emergent fifth force of nature, a field of consciousness (the consciousness field-CF) composed of an emergen...
Read more