Iris Publishers - Current Trends in Clinical & Medical Sciences (CTCMS)

 Which Invasive Electrode to Implant in Humans for Prosthetic use?

Authored by Philip Kennedy


Introduction

It has long been maintained that tine type electrodes are adequate for long-term prosthetic command signals. Even Elon Musk has developed an electrode that is claimed to record 3072 single units [1]. He further claims it can be used for long-term prosthetic devices. The tine type Utah array (Blackrockmicro Inc.) has been championed as the savior of long-term prosthetic control. However, even the researchers admit that its lifetime is limited because it loses 85% of single units within three years [2]. It suffers the fate of all foreign bodies, namely, scarring at the electrode tip. This will obviously occur with all metal and tine type electrodes that pierce the cortex. So move over Blackrock, move over Elon, there is another way to do it.

The other way has been in development since 1986. It turns the approach on its head by growing the brain neuropil into the electrode tip. A tiny glass cone is inserted into the cortex with a magic sauce inside, namely, nerve growth factors. These factors induce growth into and through the tip. In addition, the recording wires are 2 mil 99.999% gold with Teflon insulation, and these are glued inside the glass cone. Moreover, they are coiled for strain relief so there is no strain on the tip. All components are biocompatible. Here is an illustration (Figure 1).

Of course, the criticism is that it destroys cortex into which it is inserted. But so, what? This cortex, though still viable, is useless to someone who is paralyzed and mute. Another criticism is that it must cause lots of scarring and the signals will be lost. First, no data has ever shown scarring, whether in rats [3], monkeys [3] or humans [4]. The latest human subject revealed no postmortem scarring after 13 years of implantation [4]. Moreover, the histology demonstrated myelinated neurafilaments adjacent to the recording wires [4].

So the criticism is that the recorded signal have changed and died away just like the tine type electrodes. Not so. Single units are stable even as long as 10 years in the above subject [4] who was too ill to continue recording after 10 years. Conditioning studies at the end of the decade demonstrated functional single units [5,6]. Other long-term humans had functional signals at four years [7]. These studies cement its position as the long-term recording electrode.

So why is it not being used more often? It is FDA approved for use in humans (IDE 960032). I imagine it is too difficult to implant. Some have tried and failed. It requires a trained and skilled neurosurgeon for human implantation. The main reason, perhaps, is because it is not sexy enough, it looks awful, it takes a few hours to make by hand, so it is out of fashion. Millions of dollars has been spent on the tine type electrodes and no one wants to see an investment rendered useless. Indeed, the tine types have been proven extremely useful in shorter term studies (months and years) [8]. But data is data. And the data is now irrefutable for longterm studies [4-6]

To read more about this article: https://irispublishers.com/ctcms/fulltext/Which-Invasive-Electrode-to-Implant-in-Humans.ID.000520.php

Indexing List of Iris Publishers: https://medium.com/@irispublishers/what-is-the-indexing-list-of-iris-publishers-4ace353e4eee

Iris publishers google scholar citations: https://scholar.google.co.in/scholar?hl=en&as_sdt=0%2C5&q=irispublishers&btnG=


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